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    This report updates in 20-Jun-2018

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") //-- login register international mouse phenotyping consortium advanced tools impress batch query impc publications browser phenoview rest api other tools about impc objectives and background impc members governance documentation coordination industry sponsors secretariat additional information arrive guidelines about ikmc impc privacy policy news & events events references using ikmc and impc resources contact my impc impc forum documentation communications materials you are here home » about ikmc » the eucomm program eucomm - the european conditional mouse mutagenesis program is founder member and european cornerstone of the international knockout mouse consortium (ikmc). eucomm contributes the largest fraction of conditionally trapped and targeted genes in mouse c57bl/6n embryonic stem (es) cells to the ikmc. eucomm vectors, mutant es cells and mutant mice are distributed worldwide, enabling functional genomics research in a standardized and cost-effective manner by a much wider biomedical research community than has been possible previously. eucomm mutant es cells and vectors can be obtained from the european mouse mutant cell repository (eummcr). eucomm mutant mice are archived and distributed by the european mouse mutant archive (emma). eucomm farewell meeting participants eucomm project information main objectives • generation, archiving, and world-wide distribution of up to 12.000 conditional mutations across the mouse genome in mouse embryonic stem (es) cells • establishment of a limited number of mouse mutants from this resource mutagenesis strategies • conditional gene trapping - random approach for expressed genes • conditional targeted trapping - directed approach, used for expressed genes • conditional gene targeting - directed approach, used for non-expressed genes networking • generation of european mouse functional genomics platform by synergistic integration of emma, eumodic, eurexpress, flpflex ,fungenes, prime and others • cornerstone of world-wide mouse mutagenesis effort, member of the international knockout mouse consortium (ikmc) societal benefits • improvement of health research • speedup of drug development, therapy and diagnosis • competitive advantage for pharmaceutical industry funding & structure • funded by european union (fp 6, priority 1 "life sciences, genomics and biotechnology for health") • eu funding: up to 13 million euros • integrated project • consortium: 9 participants from four european countries eucomm scientific advisory board phil avner, paris, france david beier, boston, ma, usa pierre chambon, strasbourg, france deanna church, bethesda, md, usa frank grosveld, rotterdam, the netherlands monica justice, houston, tx, usa george kollias, vari, greece björn löwenadler, mölndal, sweden bernard malissen, marseille-luminy, france andrew mcmahon, cambridge, ma, usa h. earl ruley, nashville, tn, usa phil soriano, new york, ny, usa eucomm coordination wolfgang wurst allan bradley eucomm management cornelia kaloff derek matthews karin simmerl eucomm participants helmholtz zentrum münchen, german research center for environmental health gmbh (formerly gsf), munich/neuherberg, germany wolfgang wurst, martin hrabé de angelis, joel schick, andreas hörlein, cornelia kaloff, claudia seisenberger, antje bürger, karin simmerl http://www.helmholtz-muenchen.de/idg/ , http://www.helmholtz-muenchen.de/ieg/ the wellcome trust sanger institute hinxton, cambridge, uk allan bradley, william c. skarnes, barry rosen, anthony west, wendy bushell, vivek iyer, ramiro ramirez-solis, derek matthews http://www.sanger.ac.uk/htgt university of frankfurt, germany harald von melchner, frank schnütgen http://www.vonmelchner.de/ charité, berlin, germany patricia ruiz http://www.ccr.charite.de/ university of technology, dresden, germany francis stewart, konstantinos anastassiadis, andrea kranz http://www.biotec.tu-dresden.de/stewart institut clinique de la souris, strasbourg, france yann hérault, marie-christine birling, guillaume pavlovic, mohammed selloum http://www-mci.u-strasbg.fr/ european molecular biology laboratory (embl) monterotondo, italy nadia rosenthal http://www.embl-monterotondo.it/ medical research council (mrc), mammalian genetics unit, harwell, uk steve brown http://www.mgu.har.mrc.ac.uk/ consiglio nazionale delle ricerche, monterotondo, italy glauco tocchini-valentini, brendan doe http://www.emma.cnr.it/ eucomm publications 2012 highly-efficient, fluorescent, locus directed cre and flpo deleter mice on a pure c57bl/6n genetic background. birling mc, dierich a, jacquot s, hérault y, pavlovic g. genesis. 2012 jun;50(6):482-9. pmid: 22121025 doi: 10.1002/dvg.20826 the mammalian gene function resource: the international knockout mouse consortium. bradley a, anastassiadis k, ayadi a, battey jf, bell c, birling mc, bottomley j, brown sd, bürger a, bult cj, bushell w, collins fs, desaintes c, doe b, economides a, eppig jt, finnell rh, fletcher c, fray m, frendewey d, friedel rh, grosveld fg, hansen j, hérault y, hicks g, hörlein a, houghton r, hrabé de angelis m, huylebroeck d, iyer v, de jong pj, kadin ja, kaloff c, kennedy k, koutsourakis m, lloyd kck, marschall s, mason j, mckerlie c, mcleod mp, von melchner h, moore m, mujica ao, nagy a, nefedov m, nutter lm, pavlovic g, peterson jl, pollock j, ramirez-solis r, rancourt de, raspa m, remacle je, ringwald m, rosen b, rosenthal n, rossant j, ruiz noppinger p, ryder e, schick jz, schnütgen f, schofield p, seisenberger c, selloum m, simpson em, skarnes wc, smedley d, stanford wl, stewart af, stone k, swan k, tadepally h, teboul l, tocchini-valentini gp, valenzuela d, west ap, yamamura ki, yoshinaga y, wurst w. mamm genome. 2012 oct;23(9-10):580-6. pmid: 22968824 doi: 10.1007/s00335-012-9422-2 isolation of homozygous mutant mouse embryonic stem cells using a dual selection system. huang y, pettitt sj, guo g, liu g, li ma, yang f, bradley a. nucleic acids res. 2012 feb 1;40(3):e21. pmid: 22127858 doi: 10.1093/nar/gkr908 2011 high efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes. bird aw, erler a, fu j, hériché jk, maresca m, zhang y, hyman aa, stewart af. nat methods. 2011 dec 4;9(1):103-9. pmid: 22138824 doi: 10.1038/nmeth.1803 disease model discovery and translation. introduction. brown sd. mamm genome. 2011 aug;22(7-8):361. pmid: 21796466 doi: 10.1007/s00335-011-9352-4 hif-vegf pathways are critical for chronic otitis media in junbo and jeff mouse mutants. cheeseman mt, tyrer he, williams d, hough ta, pathak p, romero mr, hilton h, bali s, parker a, vizor l, purnell t, vowell k, wells s, bhutta mf, potter pk, brown sd. plos genet. 2011 oct;7(10):e1002336. pmid: 22028672 doi: 10.1371/journal.pgen.1002336 genetic screens using the piggybac transposon. chew sk, rad r, futreal pa, bradley a, liu p. methods. 2011 apr;53(4):366-71. pmid: 21185377 doi: 10.1016/j.ymeth.2010.12.022 recombineering bac transgenes for protein tagging. ciotta g, hofemeister h, maresca m, fu j, sarov m, anastassiadis k, stewart af. methods. 2011 feb;53(2):113-9. pmid: 20868752 doi: 10.1016/j.ymeth.2010.09.003 disruption of mouse slx4, a regulator of structure-specific nucleases, phenocopies fanconi anemia. crossan gp, van der weyden l, rosado iv, langevin f, gaillard ph, mcintyre re; sanger mouse genetics project, gallagher f, kettunen mi, lewis dy, brindle k, arends mj, adams dj, patel kj nat genet. 2011 feb;43(2):147-52. pmid: 21240276 doi: 10.1038/ng.752 recombination-mediated genetic engineering of large genomic dna transgenes. ejsmont rk, ahlfeld p, pozniakovsky a, stewart af, tomancak p, sarov m. methods mol biol. 2011;772:445-58. pmid: 22065454 doi: 10.1007/978-1-61779-228-1_26 forward and reverse genetics through derivation of haploid mouse embryonic stem cells. elling u, taubenschmid j, wirnsberger g, o'malley r, demers sp, vanhaelen q, shukalyuk ai, schmauss g, schramek d, schnuetgen f, von melchner h, ecker jr, stanford wl, zuber

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http://www.mousephenotype.org/about-ikmc/eucomm//objectives-and-background
https://www.mousephenotype.org/sites/mousephenotype.org/files/impc%20governance%20and%20coordination%20v02%20october%202014.pdf
http://www.mousephenotype.org/about-ikmc/eucomm//about-impc/arrive-guidelines
https://www.mousephenotype.org/data/batchquery
http://www.mousephenotype.org/about-ikmc/eucomm//user/login?current=node/90443
http://www.mousephenotype.org/about-ikmc/eucomm//contact/website-feedback?page=%2fabout-ikmc%2feucomm
http://www.mousephenotype.org/about-ikmc/eucomm//about-impc/industry-sponsors
http://www.mousephenotype.org/about-ikmc/eucomm//about-impc/impc-members
http://www.mousephenotype.org/impress
http://www.mousephenotype.org/data/alleleref
//www.mousephenotype.org/data/tools
http://www.mousephenotype.org/about-ikmc/eucomm//forum
http://www.mousephenotype.org/about-ikmc/eucomm//user/register
http://www.mousephenotype.org/about-ikmc/eucomm//about-impc/publications
http://www.mousephenotype.org/data/documentation/doc-overview
mgu.har.mrc.ac.uk
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  DNS2.SANGER.AC.UK 193.62.203.31

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